NCBI STATPEARLS + PUBMED + OPEN-I VERIFIED SEED TAXONOMY
Taxonomía Clínica Maestra de Medipaedia.org (Por Especialidad y CIE-10/11)
Matriz de referencia clínica estandarizada de 10 secciones en 19 Especialidades Médicas con códigos CIE-10/11 verificados, tríadas clásicas, pruebas diagnósticas de elección y protocolos de primera línea.
Las 19 Especialidades (60)CardiologíaNeumologíaGastroenterología y HepatologíaNefrología y UrologíaNeurologíaEndocrinología y MetabolismoHematología y OncologíaEnfermedades InfecciosasReumatología e InmunologíaUrgencias y Cuidados IntensivosCirugía General y EspecialidadesPediatríaObstetricia y GinecologíaDermatologíaPsiquiatríaOftalmología y ORLPatología y Medicina de LaboratorioTraumatología y OrtopediaRadiología e Imagen Médica
| # | Tema, Especialidad y CIE-10/11 | Tríada Clásica / Presentación | Prueba Diagnóstica de Elección | Tratamiento de Primera Línea | Estado |
|---|---|---|---|---|---|
| 51 |
Neuroleptic malignant syndrome
ICD-10: G21.0
ICD-11: 8A04.4
Psiquiatría
|
FEVER Mnemonic after dopamine D2 antagonist (Haloperidol/Olanzapine) or dopamine withdrawal: Fever (>38.5–40°C) + Encephalopathy (delirium/stupor) + Vitals unstable (autonomic lability/tachycardia/diaphoresis) + Elevated enzymes (CK >1,000–100,000 IU/L) + Lead-pipe muscle Rigidity (hyporeflexia) | Clinical diagnosis (DSM-5 / Levenson Criteria) + Markedly elevated Serum Creatine Kinase (CK), leukocytosis, metabolic acidosis, and urine myoglobin (to monitor for rhabdomyolysis-induced AKI) | Immediate cessation of causative antipsychotic (or restart dopaminergic agent if withdrawal-induced) + ICU supportive cooling & aggressive IV crystalloid hydration + IV Dantrolene (1–2.5 mg/kg) + Oral Bromocriptine (dopamine agonist) or Lorazepam | ✓ Publicado (mID 10052) |
| 52 |
Serotonin syndrome (Hunter criteria)
ICD-10: G92.0
ICD-11: NE60
Psiquiatría
|
Rapid-onset (<24h) Classic Triad after serotonergic drug (SSRI + MAOI/Tramadol/Linezolid/MDMA): Neuromuscular hyperactivity (spontaneous/inducible ankle clonus, hyperreflexia, tremor) + Autonomic hyperactivity (hyperthermia, diaphoresis, mydriasis, tachycardia) + Altered mental status (agitation/delirium) | Hunter Serotonin Toxicity Criteria (clinical diagnosis in the presence of a serotonergic agent + inducible/spontaneous/ocular clonus, agitation, diaphoresis, tremor, and hyperreflexia) | Stop all serotonergic agents immediately + Benzodiazepines (IV Lorazepam/Diazepam for agitation, tremor, and hyperthermia) + IV fluids & active cooling + Serotonin 5-HT2A antagonist Cyproheptadine (12 mg PO/NG stat then 2 mg q2h) in moderate-to-severe cases | ✓ Publicado (mID 10053) |
| 53 |
Delirium tremens (alcohol withdrawal delirium)
ICD-10: F10.231
ICD-11: 6C40.4
Psiquiatría
|
Onset 48–96 hours after last alcohol drink: Global confusion & terrifying visual/tactile hallucinations (formication / Lilliputian hallucinations) + Severe autonomic hyperactivity (fever, profuse diaphoresis, tachycardia, hypertension) + Coarse tremor / generalized tonic-clonic withdrawal seizures | Clinical assessment using CIWA-Ar Score (≥20 indicates severe withdrawal) + Serum Electrolytes (correct hypomagnesaemia, hypokalaemia, and hypophosphataemia), glucose, and LFTs | Symptom-triggered or front-loaded long-acting Benzodiazepines (Oral Chlordiazepoxide or IV Diazepam; use Lorazepam/Oxazepam in severe hepatic cirrhosis) + High-dose parenteral IV Thiamine (Pabrinex) BEFORE glucose + Magnesium/potassium replacement | ✓ Publicado (mID 10054) |