NCBI STATPEARLS + PUBMED + OPEN-I VERIFIED SEED TAXONOMY
Medipaedia.org Master Clinical Topic Taxonomy (By Specialty & ICD-10/11)
Standardized 10-Section High-Yield Clinical Reference Matrix across 19 Medical Specialties with verified ICD-10/11 codes, Classic Triads, Gold-Standard Diagnostic Tests, and First-Line Treatment Protocols.
All 19 Specialties (60)CardiologyRespiratoryGastroenterology & HepatologyNephrology & UrologyNeurologyEndocrinology & MetabolismHaematology & OncologyInfectious DiseasesRheumatology & ImmunologyEmergency Medicine & Critical CareGeneral & Specialty SurgeryPaediatricsObstetrics & GynaecologyDermatologyPsychiatryOphthalmology & ENTPathology & Laboratory MedicineMusculoskeletal & TraumaRadiology & Medical Imaging
| # | Topic, Specialty & ICD-10/11 | Classic Triad / Key Presentation | Gold-Standard Diagnostic Test | First-Line Treatment Protocol | Status |
|---|---|---|---|---|---|
| 36 |
Toxic epidermal necrolysis (SCORTEN score)
ICD-10: L51.2
ICD-11: EB13.1
Dermatology
|
Febrile prodrome after culprit drug (Allopurinol, Lamotrigine, Carbamazepine, Sulfonamides) + Painful erythematous/dusky macules with positive Nikolsky sign (>30% BSA detachment in TEN; <10% in SJS) + Haemorrhagic mucositis of ≥2 mucosal surfaces (oral, ocular, urogenital) | Clinical assessment of Body Surface Area (BSA) epidermal detachment + Skin Biopsy (frozen/paraffin section showing full-thickness epidermal keratinocyte necrosis and subepidermal split) + SCORTEN prognostic score | Immediate withdrawal of culprit drug + Transfer to ICU / Severe Burns Unit + Aggressive fluid/electrolyte & nutritional support + Non-adherent wound dressings + Urgent Ophthalmology review (Ciclosporin/Etanercept/IVIG per specialist protocol) | ✓ Published (mID 10039) |