NCBI STATPEARLS + PUBMED + OPEN-I VERIFIED SEED TAXONOMY

Medipaedia.org Master Clinical Topic Taxonomy (By Specialty & ICD-10/11)

Standardized 10-Section High-Yield Clinical Reference Matrix across 19 Medical Specialties with verified ICD-10/11 codes, Classic Triads, Gold-Standard Diagnostic Tests, and First-Line Treatment Protocols.

All 19 Specialties (60)Cardiology Respiratory Gastroenterology & Hepatology Nephrology & Urology Neurology Endocrinology & Metabolism Haematology & Oncology Infectious Diseases Rheumatology & Immunology Emergency Medicine & Critical Care General & Specialty Surgery Paediatrics Obstetrics & Gynaecology Dermatology Psychiatry Ophthalmology & ENT Pathology & Laboratory Medicine Musculoskeletal & Trauma Radiology & Medical Imaging

#	Topic, Specialty & ICD-10/11	Classic Triad / Key Presentation	Gold-Standard Diagnostic Test	First-Line Treatment Protocol	Status
28	Guillain-Barré syndrome ICD-10: G61.0 ICD-11: 8C01.0 Neurology	Progressive symmetrical ascending flaccid weakness + Areflexia/hyporeflexia + Preceding respiratory or Campylobacter jejuni GI infection 1–4 weeks prior	Lumbar Puncture CSF showing Albuminocytological Dissociation (elevated CSF protein with normal WCC <5/mm³) + Nerve Conduction Studies (demyelination / absent F-waves)	Serial Forced Vital Capacity (FVC <20 mL/kg mandates intubation/ICU) + IV Immunoglobulin (IVIG 0.4 g/kg/day for 5 days) or Plasma Exchange (corticosteroids are ineffective)	✓ Published (mID 10008)
29	Myasthenia gravis and myasthenic crisis ICD-10: G70.00 ICD-11: 8C60 Neurology	Fatigable fluctuating skeletal muscle weakness (worsening at end of day) + Ocular ptosis & diplopia + Bulbar dysphagia/dysarthria with preserved deep tendon reflexes and sensation	Serum anti-Acetylcholine Receptor (anti-AChR) antibodies (or anti-MuSK if seronegative) + Repetitive Nerve Stimulation (decremental response) / Single-fibre EMG + CT Thorax (to exclude thymoma)	Symptomatic: Pyridostigmine + Immunosuppression (Prednisolone/Azathioprine) + Thymectomy; Myasthenic Crisis: Intubation (if FVC <15–20 mL/kg) + Plasma Exchange or IVIG	✓ Published (mID 10033)
30	Wallenberg syndrome (lateral medullary syndrome) ICD-10: I63.53 ICD-11: 8B11 Neurology	Ipsilateral Horner's syndrome + Ipsilateral facial pain/temperature loss & cerebellar ataxia + Contralateral trunk/limb pain & temperature loss (+ dysphagia/hoarseness from nucleus ambiguus)	Diffusion-Weighted MRI (DWI) of the Brain & Posterior Fossa + CT/MR Angiography of the Vertebral and Posterior Inferior Cerebellar Artery (PICA)	Acute ischaemic stroke protocol (IV Alteplase/Tenecteplase if within 4.5h window) + Strict NPO & speech/swallow evaluation to prevent aspiration pneumonia + Secondary stroke prevention	✓ Published (mID 10034)
31	Wernicke encephalopathy ICD-10: E51.2 ICD-11: 5B55.1 Neurology	Classic Triad: Acute confusion/encephalopathy + Oculomotor dysfunction (horizontal nystagmus, bilateral CN VI palsy, conjugate gaze palsy) + Gait ataxia	Clinical diagnosis (MRI Brain shows symmetric T2/FLAIR hyperintensity in mammillary bodies, dorsomedial thalami, tectal plate, and periaqueductal grey)	Immediate high-dose parenteral IV Thiamine (Vitamin B1, 500 mg IV TDS for 3–5 days) ALWAYS administered BEFORE or concurrently with IV glucose to prevent precipitating Korsakoff syndrome	✓ Published (mID 10035)