NCBI STATPEARLS + PUBMED + OPEN-I VERIFIED SEED TAXONOMY

Medipaedia.org Master Clinical Topic Taxonomy (By Specialty & ICD-10/11)

Standardized 10-Section High-Yield Clinical Reference Matrix across 19 Medical Specialties with verified ICD-10/11 codes, Classic Triads, Gold-Standard Diagnostic Tests, and First-Line Treatment Protocols.

All 19 Specialties (60)Cardiology Respiratory Gastroenterology & Hepatology Nephrology & Urology Neurology Endocrinology & Metabolism Haematology & Oncology Infectious Diseases Rheumatology & Immunology Emergency Medicine & Critical Care General & Specialty Surgery Paediatrics Obstetrics & Gynaecology Dermatology Psychiatry Ophthalmology & ENT Pathology & Laboratory Medicine Musculoskeletal & Trauma Radiology & Medical Imaging

#	Topic, Specialty & ICD-10/11	Classic Triad / Key Presentation	Gold-Standard Diagnostic Test	First-Line Treatment Protocol	Status
51	Neuroleptic malignant syndrome ICD-10: G21.0 ICD-11: 8A04.4 Psychiatry	FEVER Mnemonic after dopamine D2 antagonist (Haloperidol/Olanzapine) or dopamine withdrawal: Fever (>38.5–40°C) + Encephalopathy (delirium/stupor) + Vitals unstable (autonomic lability/tachycardia/diaphoresis) + Elevated enzymes (CK >1,000–100,000 IU/L) + Lead-pipe muscle Rigidity (hyporeflexia)	Clinical diagnosis (DSM-5 / Levenson Criteria) + Markedly elevated Serum Creatine Kinase (CK), leukocytosis, metabolic acidosis, and urine myoglobin (to monitor for rhabdomyolysis-induced AKI)	Immediate cessation of causative antipsychotic (or restart dopaminergic agent if withdrawal-induced) + ICU supportive cooling & aggressive IV crystalloid hydration + IV Dantrolene (1–2.5 mg/kg) + Oral Bromocriptine (dopamine agonist) or Lorazepam	✓ Published (mID 10052)
52	Serotonin syndrome (Hunter criteria) ICD-10: G92.0 ICD-11: NE60 Psychiatry	Rapid-onset (<24h) Classic Triad after serotonergic drug (SSRI + MAOI/Tramadol/Linezolid/MDMA): Neuromuscular hyperactivity (spontaneous/inducible ankle clonus, hyperreflexia, tremor) + Autonomic hyperactivity (hyperthermia, diaphoresis, mydriasis, tachycardia) + Altered mental status (agitation/delirium)	Hunter Serotonin Toxicity Criteria (clinical diagnosis in the presence of a serotonergic agent + inducible/spontaneous/ocular clonus, agitation, diaphoresis, tremor, and hyperreflexia)	Stop all serotonergic agents immediately + Benzodiazepines (IV Lorazepam/Diazepam for agitation, tremor, and hyperthermia) + IV fluids & active cooling + Serotonin 5-HT2A antagonist Cyproheptadine (12 mg PO/NG stat then 2 mg q2h) in moderate-to-severe cases	✓ Published (mID 10053)
53	Delirium tremens (alcohol withdrawal delirium) ICD-10: F10.231 ICD-11: 6C40.4 Psychiatry	Onset 48–96 hours after last alcohol drink: Global confusion & terrifying visual/tactile hallucinations (formication / Lilliputian hallucinations) + Severe autonomic hyperactivity (fever, profuse diaphoresis, tachycardia, hypertension) + Coarse tremor / generalized tonic-clonic withdrawal seizures	Clinical assessment using CIWA-Ar Score (≥20 indicates severe withdrawal) + Serum Electrolytes (correct hypomagnesaemia, hypokalaemia, and hypophosphataemia), glucose, and LFTs	Symptom-triggered or front-loaded long-acting Benzodiazepines (Oral Chlordiazepoxide or IV Diazepam; use Lorazepam/Oxazepam in severe hepatic cirrhosis) + High-dose parenteral IV Thiamine (Pabrinex) BEFORE glucose + Magnesium/potassium replacement	✓ Published (mID 10054)