NCBI STATPEARLS + PUBMED + OPEN-I VERIFIED SEED TAXONOMY

Medipaedia.org Master Clinical Topic Taxonomy (By Specialty & ICD-10/11)

Standardized 10-Section High-Yield Clinical Reference Matrix across 19 Medical Specialties with verified ICD-10/11 codes, Classic Triads, Gold-Standard Diagnostic Tests, and First-Line Treatment Protocols.

All 19 Specialties (60)Cardiology Respiratory Gastroenterology & Hepatology Nephrology & Urology Neurology Endocrinology & Metabolism Haematology & Oncology Infectious Diseases Rheumatology & Immunology Emergency Medicine & Critical Care General & Specialty Surgery Paediatrics Obstetrics & Gynaecology Dermatology Psychiatry Ophthalmology & ENT Pathology & Laboratory Medicine Musculoskeletal & Trauma Radiology & Medical Imaging

#	Topic, Specialty & ICD-10/11	Classic Triad / Key Presentation	Gold-Standard Diagnostic Test	First-Line Treatment Protocol	Status
24	Diabetic ketoacidosis ICD-10: E10.10 ICD-11: 5A10 Endocrinology & Metabolism	UK JBDS Triad: Ketonaemia ≥3.0 mmol/L (or ketonuria ≥2+) + Blood glucose >11.0 mmol/L (or known diabetes) + Venous HCO3- <15.0 mmol/L and/or venous pH <7.3	Bedside capillary beta-hydroxybutyrate ketones + Venous Blood Gas (pH, HCO3-, anion gap, K+) + Plasma glucose	IV 0.9% NaCl resuscitation + Potassium replacement (40 mmol/L if K+ 3.5–5.5) + Fixed-Rate IV Insulin Infusion (0.1 units/kg/hr; add 10% glucose when BG <14 mmol/L)	✓ Published (mID 10004)
25	Thyroid storm (Burch-Wartofsky score) ICD-10: E05.91 ICD-11: 5A02.Z Endocrinology & Metabolism	Hyperpyrexia (>38.5–40°C) + Severe tachycardia / atrial fibrillation / high-output heart failure + CNS agitation, delirium, or coma	Clinical diagnosis supported by Burch-Wartofsky Point Scale (≥45 points highly suggestive) + Suppressed TSH (<0.01 mIU/L) and markedly elevated free T4/free T3	1. Beta-blockade (IV Propranolol/Esmolol) -> 2. Thionamide (Propylthiouracil 500–1000 mg loading then 250 mg q4h) -> 3. Lugol's Iodine (given ≥1 hour AFTER PTU) -> 4. IV Hydrocortisone (100 mg q8h)	✓ Published (mID 10030)
26	Addisonian crisis (acute adrenal insufficiency) ICD-10: E27.2 ICD-11: 5A74.1 Endocrinology & Metabolism	Vasopressor-refractory hypotensive shock + Acute abdominal pain/vomiting + Classic biochemical pattern: Hyponatraemia, Hyperkalaemia, and Hypoglycaemia	Random serum cortisol & ACTH drawn prior to steroid administration (never delay treatment for Short Synacthen / Cosyntropin stimulation test)	Immediate IV Hydrocortisone 100 mg stat bolus (followed by 200 mg/24h infusion or 50 mg q6h) + Rapid IV 0.9% Sodium chloride resuscitation + IV Dextrose for hypoglycaemia	✓ Published (mID 10031)
27	Phaeochromocytoma ICD-10: D35.00 ICD-11: 2F37 Endocrinology & Metabolism	Classic Episodic Triad: Paroxysmal headache + Profuse diaphoresis + Palpitations/tachycardia with severe episodic or sustained hypertension	Plasma free metanephrines or 24-hour urinary fractionated metanephrines and catecholamines + Adrenal CT/MRI (T2 'light-bulb' hyperintensity) ± 68Ga-DOTATATE PET	Pre-operative Alpha-blockade FIRST (Phenoxybenzamine or Doxazosin for 10–14 days) + high-sodium/fluid intake, FOLLOWED BY Beta-blockade (never give beta-blocker before alpha-blockade), then Laparoscopic Adrenalectomy	✓ Published (mID 10032)