NCBI STATPEARLS + PUBMED + OPEN-I VERIFIED SEED TAXONOMY

Medipaedia.org Master Clinical Topic Taxonomy (By Specialty & ICD-10/11)

Standardized 10-Section High-Yield Clinical Reference Matrix across 19 Medical Specialties with verified ICD-10/11 codes, Classic Triads, Gold-Standard Diagnostic Tests, and First-Line Treatment Protocols.

All 19 Specialties (60)Cardiology Respiratory Gastroenterology & Hepatology Nephrology & Urology Neurology Endocrinology & Metabolism Haematology & Oncology Infectious Diseases Rheumatology & Immunology Emergency Medicine & Critical Care General & Specialty Surgery Paediatrics Obstetrics & Gynaecology Dermatology Psychiatry Ophthalmology & ENT Pathology & Laboratory Medicine Musculoskeletal & Trauma Radiology & Medical Imaging

#	Topic, Specialty & ICD-10/11	Classic Triad / Key Presentation	Gold-Standard Diagnostic Test	First-Line Treatment Protocol	Status
21	Acute appendicitis ICD-10: K35.80 ICD-11: DB10.0 General & Specialty Surgery	Migratory periumbilical pain localising to McBurney's point (RIF) + Anorexia/nausea + Rebound tenderness / Rovsing's / Psoas / Obturator sign & low-grade pyrexia	Contrast-enhanced CT Abdomen & Pelvis in adults (appendiceal diameter >6 mm, wall thickening, periappendiceal fat stranding); Graded-compression Ultrasound in children/pregnancy	Laparoscopic Appendicectomy + Perioperative IV broad-spectrum antibiotics (e.g., Cefuroxime + Metronidazole or Co-amoxiclav)	✓ Published (mID 10015)
22	Boerhaave syndrome (oesophageal perforation) ICD-10: K22.3 ICD-11: DA25.2 General & Specialty Surgery	Mackler's Triad: Forceful retching/vomiting + Sudden severe lower thoracic/epigastric chest pain + Subcutaneous cervical emphysema (+ Hamman's crunch)	CT Thorax/Oesophagography with water-soluble oral contrast (Gastrografin — NEVER barium due to mediastinitis risk) showing transmural posterolateral left distal oesophageal leak	NPO + Nasogastric decompression + Broad-spectrum IV antibiotics & antifungals + Urgent primary surgical repair (<24h) or endoscopic covered stent/vacuum therapy	✓ Published (mID 10028)
23	Acute mesenteric ischaemia ICD-10: K55.0 ICD-11: DD30.0 General & Specialty Surgery	Sudden severe abdominal pain out of proportion to physical examination findings + Gut emptying (vomiting/diarrhoea) + Embolic source (Atrial fibrillation) & rising serum lactate	Biphasic CT Mesenteric Angiography (CTA) demonstrating superior mesenteric artery (SMA) thromboembolism, absent bowel wall enhancement, or pneumatosis intestinalis	Immediate IV unfractionated heparin + Fluid resuscitation + Broad-spectrum antibiotics + Emergent endovascular/open SMA embolectomy and laparotomy for necrotic bowel resection	✓ Published (mID 10029)