NCBI STATPEARLS + PUBMED + OPEN-I VERIFIED SEED TAXONOMY
Medipaedia.org Master Clinical Topic Taxonomy (By Specialty & ICD-10/11)
Standardized 10-Section High-Yield Clinical Reference Matrix across 19 Medical Specialties with verified ICD-10/11 codes, Classic Triads, Gold-Standard Diagnostic Tests, and First-Line Treatment Protocols.
All 19 Specialties (60)CardiologyRespiratoryGastroenterology & HepatologyNephrology & UrologyNeurologyEndocrinology & MetabolismHaematology & OncologyInfectious DiseasesRheumatology & ImmunologyEmergency Medicine & Critical CareGeneral & Specialty SurgeryPaediatricsObstetrics & GynaecologyDermatologyPsychiatryOphthalmology & ENTPathology & Laboratory MedicineMusculoskeletal & TraumaRadiology & Medical Imaging
| # | Topic, Specialty & ICD-10/11 | Classic Triad / Key Presentation | Gold-Standard Diagnostic Test | First-Line Treatment Protocol | Status |
|---|---|---|---|---|---|
| 37 |
Heparin-induced thrombocytopenia (HIT)
ICD-10: D75.82
ICD-11: 3B64.13
Haematology & Oncology
|
4Ts Score: Platelet count fall >50% (nadir typically 20–100 × 10⁹/L) + Onset 5–10 days after starting UFH/LMWH + Paradoxical arterial or venous thrombosis (white clot syndrome) with absence of other causes | 4Ts Pre-test Probability Score + Anti-PF4/heparin IgG ELISA immunoassay, confirmed by functional Serotonin Release Assay (SRA) or HIPA | STOP all heparin immediately (including heparin flushes and LMWH) + Start non-heparin therapeutic anticoagulation (Argatroban, Bivalirudin, Fondaparinux, or Danaparoid; avoid warfarin until platelets recover >150 × 10⁹/L; avoid platelet transfusions) | ✓ Published (mID 10040) |
| 38 |
Thrombotic thrombocytopenic purpura (TTP)
ICD-10: M31.1
ICD-11: 3B64.14
Haematology & Oncology
|
Classic Pentad: Microangiopathic haemolytic anaemia (MAHA with schistocytes) + Severe thrombocytopenia + Fluctuating neurological deficits + Renal impairment + Fever (caused by severe ADAMTS13 deficiency <10%) | Peripheral Blood Film (numerous schistocytes) + PLASMIC Score + Severe ADAMTS13 activity deficiency (<10%) with anti-ADAMTS13 autoantibodies | Emergency daily Plasma Exchange (PEX) started within 4–8 hours + High-dose Corticosteroids (Methylprednisolone) + Rituximab + Caplacizumab (anti-vWF nanobody); NEVER transfuse platelets unless life-threatening haemorrhage | + Generate / Claim |