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NCBI STATPEARLS + PUBMED + OPEN-I VERIFIED SEED TAXONOMY

Medipaedia.org Master Clinical Topic Taxonomy (By Specialty & ICD-10/11)

Standardized 10-Section High-Yield Clinical Reference Matrix across 19 Medical Specialties with verified ICD-10/11 codes, Classic Triads, Gold-Standard Diagnostic Tests, and First-Line Treatment Protocols.

All 19 Specialties (60)CardiologyRespiratoryGastroenterology & HepatologyNephrology & UrologyNeurologyEndocrinology & MetabolismHaematology & OncologyInfectious DiseasesRheumatology & ImmunologyEmergency Medicine & Critical CareGeneral & Specialty SurgeryPaediatricsObstetrics & GynaecologyDermatologyPsychiatryOphthalmology & ENTPathology & Laboratory MedicineMusculoskeletal & TraumaRadiology & Medical Imaging
# Topic, Specialty & ICD-10/11 Classic Triad / Key Presentation Gold-Standard Diagnostic Test First-Line Treatment Protocol Status
44 Acute bacterial meningitis
ICD-10: G00.9 ICD-11: 1D01.0 Infectious Diseases
Classic Triad: Fever + Neck stiffness (nuchal rigidity) + Altered mental status/photophobia (+ Kernig's sign, Brudzinski's sign, and non-blanching petechial/purpuric rash in meningococcal septicaemia) Lumbar Puncture CSF Analysis (elevated opening pressure, turbid appearance, polymorphonuclear pleocytosis >1000/mm³, CSF protein >1 g/L, CSF:serum glucose ratio <0.4) + CSF PCR & Blood Cultures Immediate IV Ceftriaxone (2 g BD) + IV Dexamethasone (10 mg q6h for 4 days given before or with first antibiotic dose) + Add IV Amoxicillin (2 g q4h) if age >50, immunocompromised, or pregnant (Listeria coverage) ✓ Published (mID 10045)
45 Sepsis and septic shock (Sepsis-3 criteria)
ICD-10: A41.9 ICD-11: 1G40 Infectious Diseases
Sepsis-3: Suspected/confirmed infection + Acute SOFA score increase ≥2 points; Septic Shock adds: Vasopressor requirement to maintain MAP ≥65 mmHg + Serum Lactate >2.0 mmol/L despite adequate fluid resuscitation 2 sets of Blood Cultures (aerobic & anaerobic) prior to antimicrobials + Serial Arterial/Venous Serum Lactate + Full SOFA organ dysfunction panel (PaO2/FiO2, platelets, bilirubin, creatinine, GCS, MAP) Sepsis Six / Surviving Sepsis 1-Hour Bundle: IV broad-spectrum antimicrobials within 1 hour + 30 mL/kg balanced crystalloid for hypotension/lactate ≥4 mmol/L + Early Noradrenaline vasopressor targeting MAP ≥65 mmHg + Source control ✓ Published (mID 10046)
46 Severe falciparum malaria
ICD-10: B50.0 ICD-11: 1F40 Infectious Diseases
Cyclical fever/rigors in returning traveller from endemic region + Thick & thin blood film showing Plasmodium falciparum hyperparasitaemia (>2–5%) / Maurer's clefts + Cerebral malaria, severe anaemia, hypoglycaemia, metabolic acidosis, or blackwater fever (AKI) 3 serial Giemsa-stained Thick (sensitivity) and Thin (species identification & percentage parasitaemia) Peripheral Blood Films + Rapid Diagnostic Antigen Test (HRP2/pLDH) Parenteral IV Artesunate (2.4 mg/kg at 0, 12, and 24 hours, then daily) followed by a full 3-day oral Artemisinin-based Combination Therapy (ACT, e.g., Artemether-lumefantrine) + Strict blood glucose monitoring ✓ Published (mID 10047)
47 Dengue haemorrhagic fever and dengue shock syndrome
ICD-10: A97.2 ICD-11: 1D2Z Infectious Diseases
Defervescence critical phase (Days 3–7): High fever with retro-orbital headache/myalgia + Progressive thrombocytopenia (<100 × 10⁹/L) with rising haematocrit (≥20% haemoconcentration from plasma leakage) + Narrow pulse pressure (≤20 mmHg) / pleural effusion / ascites Dengue NS1 Antigen ELISA/Rapid Test (Days 1–5) + Dengue IgM/IgG MAC-ELISA (Day ≥5) + Serial hourly Haematocrit (PCV) and Platelet monitoring Protocolized judicious isotonic crystalloid titration (0.9% NaCl / Ringer's Lactate guided by hourly urine output 0.5–1 mL/kg/h and serial haematocrit; rescue colloid/blood transfusion if refractory shock; strictly avoid NSAIDs/Aspirin) ✓ Published (mID 10048)