NCBI STATPEARLS + PUBMED + OPEN-I VERIFIED SEED TAXONOMY

Medipaedia.org Master Clinical Topic Taxonomy (By Specialty & ICD-10/11)

Standardized 10-Section High-Yield Clinical Reference Matrix across 19 Medical Specialties with verified ICD-10/11 codes, Classic Triads, Gold-Standard Diagnostic Tests, and First-Line Treatment Protocols.

All 19 Specialties (60)Cardiology Respiratory Gastroenterology & Hepatology Nephrology & Urology Neurology Endocrinology & Metabolism Haematology & Oncology Infectious Diseases Rheumatology & Immunology Emergency Medicine & Critical Care General & Specialty Surgery Paediatrics Obstetrics & Gynaecology Dermatology Psychiatry Ophthalmology & ENT Pathology & Laboratory Medicine Musculoskeletal & Trauma Radiology & Medical Imaging

#	Topic, Specialty & ICD-10/11	Classic Triad / Key Presentation	Gold-Standard Diagnostic Test	First-Line Treatment Protocol	Status
32	Pre-eclampsia and eclampsia ICD-10: O14.9 ICD-11: JA24 Obstetrics & Gynaecology	New-onset hypertension (BP ≥140/90 mmHg) after 20 weeks' gestation + Proteinuria (urine PCR ≥30 mg/mmol or ≥300 mg/24h) or maternal end-organ dysfunction (thrombocytopenia, elevated transaminases, renal insufficiency, pulmonary oedema, visual/cerebral symptoms)	Repeated BP measurements + Spot Urine Protein:Creatinine Ratio (PCR ≥30 mg/mmol) + sFlt-1:PlGF ratio + FBC, LFTs, Creatinine, and Fetal Umbilical Artery Doppler	Antihypertensive control (Oral Labetalol, Nifedipine MR, or Methyldopa; IV Labetalol/Hydralazine if BP ≥160/110) + IV Magnesium sulfate (4 g loading over 15–20 min then 1 g/hr infusion) for seizure prophylaxis/eclampsia + Definitive delivery	✓ Published (mID 10017)
33	HELLP syndrome ICD-10: O14.2 ICD-11: JA24.2 Obstetrics & Gynaecology	Tennessee Criteria Triad: Haemolysis (schistocytes on blood film, LDH ≥600 IU/L, or bilirubin ≥1.2 mg/dL) + Elevated Liver enzymes (AST/ALT ≥2× ULN) + Low Platelets (<100 × 10⁹/L) with RUQ/epigastric pain	Peripheral Blood Smear (schistocytes/helmet cells) + Serum LDH, haptoglobin, AST/ALT, and platelet count	Maternal stabilization (IV Magnesium sulfate for eclampsia prophylaxis + IV Labetalol/Nifedipine for severe hypertension) + Prompt delivery once maternal coagulopathy/BP stabilized (if ≥34 weeks or deteriorating)	✓ Published (mID 10036)
34	Ectopic pregnancy ICD-10: O00.9 ICD-11: JA01 Obstetrics & Gynaecology	Amenorrhoea (6–8 weeks) + Unilateral iliac fossa/pelvic pain + Vaginal bleeding (+ shoulder-tip pain and haemodynamic shock if ruptured)	Transvaginal Ultrasound (TVUS showing empty uterine cavity with adnexal mass / 'tubal ring sign' / free fluid in Pouch of Douglas) + Serial serum quantitative beta-hCG (48h rise <63%)	Ruptured/haemodynamically unstable or fetal heartbeat or beta-hCG >5000 IU/L: Laparoscopic Salpingectomy; Unruptured, stable, adnexal mass <35 mm, beta-hCG <1500–5000 IU/L: Single-dose IM Methotrexate (50 mg/m²)	✓ Published (mID 10037)