NCBI STATPEARLS + PUBMED + OPEN-I VERIFIED SEED TAXONOMY

Medipaedia.org Master Clinical Topic Taxonomy (By Specialty & ICD-10/11)

Standardized 10-Section High-Yield Clinical Reference Matrix across 19 Medical Specialties with verified ICD-10/11 codes, Classic Triads, Gold-Standard Diagnostic Tests, and First-Line Treatment Protocols.

All 19 Specialties (60)Cardiology Respiratory Gastroenterology & Hepatology Nephrology & Urology Neurology Endocrinology & Metabolism Haematology & Oncology Infectious Diseases Rheumatology & Immunology Emergency Medicine & Critical Care General & Specialty Surgery Paediatrics Obstetrics & Gynaecology Dermatology Psychiatry Ophthalmology & ENT Pathology & Laboratory Medicine Musculoskeletal & Trauma Radiology & Medical Imaging

#	Topic, Specialty & ICD-10/11	Classic Triad / Key Presentation	Gold-Standard Diagnostic Test	First-Line Treatment Protocol	Status
57	High anion gap metabolic acidosis (GOLD MARK) ICD-10: E87.2 ICD-11: 5C73 Pathology & Laboratory Medicine	Arterial pH <7.35 + Serum Bicarbonate (HCO3-) <22 mmol/L + Elevated Serum Anion Gap ([Na+] - ([Cl-] + [HCO3-])) >12 mmol/L (adjusted for hypoalbuminaemia) with compensatory Kussmaul hyperventilation (Winter's formula: PaCO2 = 1.5 × [HCO3-] + 8 ± 2)	Arterial Blood Gas (ABG) + Serum Electrolytes & Albumin-Corrected Anion Gap + Delta Ratio (ΔAG / ΔHCO3-) + Serum Osms & Osmolar Gap + Lactate, Beta-hydroxybutyrate, Urinalysis (oxalate crystals), and Salicylate/Toxicology screen	Treat the underlying GOLD MARK cause (Glycols -> Fomepizole/Haemodialysis; Oxoproline -> stop paracetamol/NAC; L-lactate -> shock resuscitation; D-lactate -> short-bowel antibiotics; Methanol -> Fomepizole; Aspirin -> urinary alkalinisation with IV NaHCO3; Renal failure -> RRT; Ketoacidosis -> Insulin/fluids)	✓ Published (mID 10058)
58	Disseminated intravascular coagulation (ISTH score) ICD-10: D65 ICD-11: 3B62.0 Pathology & Laboratory Medicine	Systemic thrombo-haemorrhagic activation (triggered by sepsis, obstetric catastrophe, trauma, or APL/malignancy) + Diffuse mucocutaneous oozing from venepuncture sites / purpura fulminans + Microvascular thrombosis causing multi-organ dysfunction	ISTH Overt DIC Scoring System (≥5 points): Thrombocytopenia (<100 × 10⁹/L) + Prolonged PT and APTT + Markedly elevated D-dimer / Fibrin Degradation Products + Consumed low Fibrinogen (<1.0–1.5 g/L) + Schistocytes on peripheral blood smear	Aggressively treat the underlying trigger (sepsis/obstetric/APL) + Supportive blood component replacement in bleeding patients: Platelets (keep >50 × 10⁹/L), Fresh Frozen Plasma (15 mL/kg for prolonged PT/APTT), and Cryoprecipitate or Fibrinogen concentrate (if fibrinogen <1.5 g/L)	✓ Published (mID 10059)