NCBI STATPEARLS + PUBMED + OPEN-I VERIFIED SEED TAXONOMY

Medipaedia.org Master Clinical Topic Taxonomy (By Specialty & ICD-10/11)

Standardized 10-Section High-Yield Clinical Reference Matrix across 19 Medical Specialties with verified ICD-10/11 codes, Classic Triads, Gold-Standard Diagnostic Tests, and First-Line Treatment Protocols.

All 19 Specialties (60)Cardiology Respiratory Gastroenterology & Hepatology Nephrology & Urology Neurology Endocrinology & Metabolism Haematology & Oncology Infectious Diseases Rheumatology & Immunology Emergency Medicine & Critical Care General & Specialty Surgery Paediatrics Obstetrics & Gynaecology Dermatology Psychiatry Ophthalmology & ENT Pathology & Laboratory Medicine Musculoskeletal & Trauma Radiology & Medical Imaging

#	Topic, Specialty & ICD-10/11	Classic Triad / Key Presentation	Gold-Standard Diagnostic Test	First-Line Treatment Protocol	Status
59	Subarachnoid haemorrhage ICD-10: I60.9 ICD-11: 8B01 Radiology & Medical Imaging	Sudden-onset 'thunderclap' occipital headache reaching maximal intensity within seconds to <1–5 minutes + Meningism (neck stiffness, photophobia, vomiting) + Transient loss of consciousness or focal cranial nerve palsy (e.g., pupil-involving CN III palsy from PCom aneurysm)	Non-contrast CT Head within 6 hours of headache onset (>98.5% sensitivity showing hyperdense blood in basal cisterns/Sylvian fissures); if CT negative >6 hours -> Lumbar Puncture at ≥12 hours for CSF Spectrophotometry (bilirubin xanthochromia) + CT Angiography (CTA) / Digital Subtraction Angiography (DSA)	Neurosurgical ICU admission + Oral Nimodipine (60 mg q4h for 21 days to prevent delayed cerebral ischaemia/vasospasm) + BP control (SBP <160 mmHg pre-securing) + Urgent Endovascular Coiling or Microsurgical Clipping of ruptured berry aneurysm within 24–72 hours	✓ Published (mID 10060)
60	Acute ischaemic stroke (ASPECTS and NIHSS) ICD-10: I63.9 ICD-11: 8B11 Radiology & Medical Imaging	Sudden-onset focal neurological deficit conforming to a vascular territory (FAST: Contralateral hemiparesis, facial droop, aphasia/dysarthria, gaze deviation, or homonymous hemianopia) + NIHSS quantification + Hyperdense MCA sign / loss of insular ribbon on non-contrast CT	Immediate Non-Contrast CT Head (to exclude haemorrhage and calculate ASPECTS score) + CT Angiography (arch-to-vertex for Large Vessel Occlusion in ICA/M1/M2/Basilar) + CT Perfusion (core-to-penumbra mismatch in 6–24h window)	IV Thrombolysis within 4.5 hours of onset (Alteplase 0.9 mg/kg or Tenecteplase 0.25 mg/kg after excluding haemorrhage; keep BP <185/110 mmHg) + Mechanical Endovascular Thrombectomy within 6–24 hours for anterior/posterior Large Vessel Occlusion + Aspirin 300 mg started 24h post-thrombolysis after repeat CT	✓ Published (mID 10061)