NCBI STATPEARLS + PUBMED + OPEN-I VERIFIED SEED TAXONOMY

Medipaedia.org Master Clinical Topic Taxonomy (By Specialty & ICD-10/11)

Standardized 10-Section High-Yield Clinical Reference Matrix across 19 Medical Specialties with verified ICD-10/11 codes, Classic Triads, Gold-Standard Diagnostic Tests, and First-Line Treatment Protocols.

All 19 Specialties (60)Cardiology Respiratory Gastroenterology & Hepatology Nephrology & Urology Neurology Endocrinology & Metabolism Haematology & Oncology Infectious Diseases Rheumatology & Immunology Emergency Medicine & Critical Care General & Specialty Surgery Paediatrics Obstetrics & Gynaecology Dermatology Psychiatry Ophthalmology & ENT Pathology & Laboratory Medicine Musculoskeletal & Trauma Radiology & Medical Imaging

#	Topic, Specialty & ICD-10/11	Classic Triad / Key Presentation	Gold-Standard Diagnostic Test	First-Line Treatment Protocol	Status
48	Systemic lupus erythematosus (EULAR/ACR criteria) ICD-10: M32.9 ICD-11: 4A40.0 Rheumatology & Immunology	Entry criterion ANA ≥1:80 + Mucocutaneous (malar butterfly rash sparing nasolabial folds, photosensitivity, oral ulcers) + Non-erosive polyarthritis / Serositis / Lupus nephritis / Cytopenias with hypocomplementaemia (low C3/C4)	Antinuclear Antibody (ANA ≥1:80 screening) + High-specificity Anti-dsDNA (correlates with lupus nephritis disease activity) and Anti-Smith (Anti-Sm) antibodies + Complement C3/C4 + Urine PCR/Renal Biopsy	Universal Hydroxychloroquine (≤5 mg/kg/day for all patients unless contraindicated) + Photoprotection + Corticosteroids for flares + Mycophenolate mofetil / Cyclophosphamide / Belimumab / Rituximab for organ-threatening Lupus Nephritis	✓ Published (mID 10049)
49	Giant cell arteritis (temporal arteritis) ICD-10: M31.6 ICD-11: 4A44.2 Rheumatology & Immunology	Age >50 years with new unilateral temporal headache & scalp tenderness + Jaw claudication + Visual disturbance (amaurosis fugax / anterior ischaemic optic neuropathy) & Polymyalgia rheumatica with ESR >50 mm/hr / elevated CRP	Colour Duplex Ultrasound of the Temporal & Axillary Arteries (non-compressible hypoechoic 'halo sign') + Temporal Artery Biopsy within 2 weeks of starting steroids (granulomatous panarteritis with multinucleated giant cells and internal elastic lamina fragmentation)	IMMEDIATE High-Dose Corticosteroids (NEVER wait for biopsy): Visual symptoms present -> IV Methylprednisolone 500–1000 mg daily for 3 days then Prednisolone 60 mg OD; No visual loss -> Oral Prednisolone 40–60 mg OD + Tocilizumab (IL-6 inhibitor) steroid-sparing therapy	✓ Published (mID 10050)
50	Septic arthritis ICD-10: M00.9 ICD-11: FA10 Rheumatology & Immunology	Acute hot, swollen, erythematous monoarthritis + Severe pain with complete inability to bear weight or tolerate passive range of motion + Fever & elevated CRP/ESR/WCC (Kocher criteria in paediatric hip)	Urgent Synovial Fluid Aspiration PRIOR to antibiotics (Synovial WCC >50,000/mm³ with >90% neutrophils, Gram stain, culture, and polarized light microscopy to exclude crystal arthropathy) + Blood Cultures	Emergency arthroscopic or open surgical joint washout/debridement + Empiric IV antibiotics (Flucloxacillin or Vancomycin + Ceftriaxone if gonococcal/Gram-negative risk) for 4–6 weeks	✓ Published (mID 10051)