NCBI STATPEARLS + PUBMED + OPEN-I VERIFIED SEED TAXONOMY

Taxonomía Clínica Maestra de Medipaedia.org (Por Especialidad y CIE-10/11)

Matriz de referencia clínica estandarizada de 10 secciones en 19 Especialidades Médicas con códigos CIE-10/11 verificados, tríadas clásicas, pruebas diagnósticas de elección y protocolos de primera línea.

Las 19 Especialidades (60)Cardiología Neumología Gastroenterología y Hepatología Nefrología y Urología Neurología Endocrinología y Metabolismo Hematología y Oncología Enfermedades Infecciosas Reumatología e Inmunología Urgencias y Cuidados Intensivos Cirugía General y Especialidades Pediatría Obstetricia y Ginecología Dermatología Psiquiatría Oftalmología y ORL Patología y Medicina de Laboratorio Traumatología y Ortopedia Radiología e Imagen Médica

#	Tema, Especialidad y CIE-10/11	Tríada Clásica / Presentación	Prueba Diagnóstica de Elección	Tratamiento de Primera Línea	Estado
44	Acute bacterial meningitis ICD-10: G00.9 ICD-11: 1D01.0 Enfermedades Infecciosas	Classic Triad: Fever + Neck stiffness (nuchal rigidity) + Altered mental status/photophobia (+ Kernig's sign, Brudzinski's sign, and non-blanching petechial/purpuric rash in meningococcal septicaemia)	Lumbar Puncture CSF Analysis (elevated opening pressure, turbid appearance, polymorphonuclear pleocytosis >1000/mm³, CSF protein >1 g/L, CSF:serum glucose ratio <0.4) + CSF PCR & Blood Cultures	Immediate IV Ceftriaxone (2 g BD) + IV Dexamethasone (10 mg q6h for 4 days given before or with first antibiotic dose) + Add IV Amoxicillin (2 g q4h) if age >50, immunocompromised, or pregnant (Listeria coverage)	✓ Publicado (mID 10045)
45	Sepsis and septic shock (Sepsis-3 criteria) ICD-10: A41.9 ICD-11: 1G40 Enfermedades Infecciosas	Sepsis-3: Suspected/confirmed infection + Acute SOFA score increase ≥2 points; Septic Shock adds: Vasopressor requirement to maintain MAP ≥65 mmHg + Serum Lactate >2.0 mmol/L despite adequate fluid resuscitation	2 sets of Blood Cultures (aerobic & anaerobic) prior to antimicrobials + Serial Arterial/Venous Serum Lactate + Full SOFA organ dysfunction panel (PaO2/FiO2, platelets, bilirubin, creatinine, GCS, MAP)	Sepsis Six / Surviving Sepsis 1-Hour Bundle: IV broad-spectrum antimicrobials within 1 hour + 30 mL/kg balanced crystalloid for hypotension/lactate ≥4 mmol/L + Early Noradrenaline vasopressor targeting MAP ≥65 mmHg + Source control	✓ Publicado (mID 10046)
46	Severe falciparum malaria ICD-10: B50.0 ICD-11: 1F40 Enfermedades Infecciosas	Cyclical fever/rigors in returning traveller from endemic region + Thick & thin blood film showing Plasmodium falciparum hyperparasitaemia (>2–5%) / Maurer's clefts + Cerebral malaria, severe anaemia, hypoglycaemia, metabolic acidosis, or blackwater fever (AKI)	3 serial Giemsa-stained Thick (sensitivity) and Thin (species identification & percentage parasitaemia) Peripheral Blood Films + Rapid Diagnostic Antigen Test (HRP2/pLDH)	Parenteral IV Artesunate (2.4 mg/kg at 0, 12, and 24 hours, then daily) followed by a full 3-day oral Artemisinin-based Combination Therapy (ACT, e.g., Artemether-lumefantrine) + Strict blood glucose monitoring	✓ Publicado (mID 10047)
47	Dengue haemorrhagic fever and dengue shock syndrome ICD-10: A97.2 ICD-11: 1D2Z Enfermedades Infecciosas	Defervescence critical phase (Days 3–7): High fever with retro-orbital headache/myalgia + Progressive thrombocytopenia (<100 × 10⁹/L) with rising haematocrit (≥20% haemoconcentration from plasma leakage) + Narrow pulse pressure (≤20 mmHg) / pleural effusion / ascites	Dengue NS1 Antigen ELISA/Rapid Test (Days 1–5) + Dengue IgM/IgG MAC-ELISA (Day ≥5) + Serial hourly Haematocrit (PCV) and Platelet monitoring	Protocolized judicious isotonic crystalloid titration (0.9% NaCl / Ringer's Lactate guided by hourly urine output 0.5–1 mL/kg/h and serial haematocrit; rescue colloid/blood transfusion if refractory shock; strictly avoid NSAIDs/Aspirin)	✓ Publicado (mID 10048)